Uter W, Lessmann H, Geier J, Becker D, Fuchs T, Richter G
Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Allergy. 2002 Apr;57(4):319-22. doi: 10.1034/j.1398-9995.2002.1o3314.x.
Allergic contact sensitization to 'para amino' compounds is frequent and the spectrum of cross-reactivity between members of this chemical group is variable.
A retrospective analysis of clinical patch test data obtained with a special test series in the centres of the Information Network of Departments of Dermatology (IVDK) between 1995 and 1999.
In the 638 patients tested with the above test panel positive reactions were observed most often to p-aminoazobenzene (16.2%), p-phenylenediamine (14.1%), p-toluylenediamine (10.0%), followed by 4,4'-diaminodiphenylmethane (8.5%), Disperse Orange 3 (8.4%) and p-aminophenol (3.1%). Among the 544 patients tested with p-phenylenediamine and all seven additional 'para amino' compounds, concordance between reactions varied greatly. The stronger the positive test reaction to p-phenylenediamine, p-toluylenediamine or p-aminoazobenzene, the more frequently additional positive reactions to the other compounds were observed.
A screening employing several 'para amino' compounds is necessary to describe the individual spectrum of allergic contact sensitization, as there is no reliable marker substance. Further research should aim at (i) establishing the mechanism of cross-reactivity to 'para amino' compounds and (ii) identifying exposures in the environment.
对“对氨基”化合物的过敏性接触致敏很常见，且该化学基团成员之间的交叉反应谱各不相同。
对1995年至1999年间在皮肤病学部门信息网络（IVDK）各中心使用特殊测试系列获得的临床斑贴试验数据进行回顾性分析。
在使用上述测试组进行测试的638例患者中，最常观察到对氨基偶氮苯（16.2%）、对苯二胺（14.1%）、对甲苯二胺（10.0%）呈阳性反应，其次是4,4'-二氨基二苯甲烷（8.5%）、分散橙3（8.4%）和对氨基酚（3.1%）。在使用对苯二胺和另外七种“对氨基”化合物进行测试的544例患者中，反应之间的一致性差异很大。对对苯二胺、对甲苯二胺或对氨基偶氮苯的阳性测试反应越强，对其他化合物的额外阳性反应出现得就越频繁。
由于没有可靠的标志物物质，采用几种“对氨基”化合物进行筛查对于描述个体过敏性接触致敏谱是必要的。进一步的研究应旨在（i）确定对“对氨基”化合物交叉反应的机制，以及（ii）识别环境中的暴露因素。
