Roesler Rafael, Roozendaal Benno, McGaugh James L
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA.
Eur J Neurosci. 2002 Mar;15(5):905-10. doi: 10.1046/j.1460-9568.2002.01924.x.
There is extensive evidence suggesting that the basolateral nucleus of the amygdala plays a critical role in modulating memory consolidation processes in other brain regions. The present experiments examined interactions between the basolateral amygdala and the entorhinal cortex in modulating memory consolidation for inhibitory avoidance training. Several studies have reported that activation of the second messenger system adenosine 3',5'-cyclic monophosphate (cAMP) in several brain regions enhances memory and induces long-term plasticity. In the present experiments, a unilateral infusion of the cAMP analogue, 8-Br-cAMP (0.25 or 1.25 microg in 0.5 microL), administered into the entorhinal cortex of male Sprague-Dawley rats immediately after training, enhanced 48-h retention. An N-methyl-d-aspartate-induced lesion of the ipsilateral basolateral amygdala did not impair retention, but blocked the memory-enhancing effect of 8-Br-cAMP (infused into the entorhinal cortex) post-training. A lesion of the contralateral basolateral amygdala did not block the 8-Br-cAMP-induced retention enhancement. These findings indicate that an intact basolateral amygdala is essential for modulation of memory consolidation involving the entorhinal cortex, and are consistent with evidence that the basolateral amygdala regulates memory consolidation mediated by other brain regions.
有大量证据表明，杏仁核基底外侧核在调节其他脑区的记忆巩固过程中起关键作用。本实验研究了杏仁核基底外侧核与内嗅皮质在调节抑制性回避训练记忆巩固中的相互作用。几项研究报告称，几个脑区中第二信使系统3',5'-环磷酸腺苷（cAMP）的激活可增强记忆并诱导长期可塑性。在本实验中，训练后立即向雄性Sprague-Dawley大鼠的内嗅皮质单侧注射cAMP类似物8-溴-cAMP（0.5微升中含0.25或1.25微克），可增强48小时的记忆保持。同侧杏仁核基底外侧核的N-甲基-D-天冬氨酸诱导损伤并未损害记忆保持，但阻断了训练后注入内嗅皮质的8-溴-cAMP的记忆增强作用。对侧杏仁核基底外侧核的损伤并未阻断8-溴-cAMP诱导的记忆保持增强。这些发现表明，完整的杏仁核基底外侧核对于涉及内嗅皮质的记忆巩固调节至关重要，并且与杏仁核基底外侧核调节由其他脑区介导的记忆巩固的证据一致。
