Rodriguez-Sosa Miriam, David John R, Bojalil Rafael, Satoskar Abhay R, Terrazas Luis I
Department of Immunology, Instituto Nacional de Cardiologia "Ignacio Chavez," Mexico, D.F. Mexico.
J Immunol. 2002 Apr 1;168(7):3135-9. doi: 10.4049/jimmunol.168.7.3135.
Using STAT6(-/-) BALB/c mice, we analyzed the role of STAT6-induced Th2 response in determining the outcome of murine cysticercosis caused by the helminth parasite Taenia crassiceps. After T. crassiceps infection, wild-type BALB/c mice developed a strong Th2-like response; produced high levels of IgG1, IgE, IL-4, as well as IL-13; and remained susceptible to T. crassiceps. In contrast, similarly infected STAT6(-/-) mice mounted a strong Th1-like response; produced high levels of IgG2a, IL-12, IFN-gamma, as well as nitric oxide; and efficiently controlled T. crassiceps infection. These findings demonstrate that Th2-like response induced via STAT6-mediated signaling pathway mediates susceptibility to T. crassiceps and, furthermore, that unlike the case in most helminths, immunity against T. crassiceps is mediated by a Th1-like rather than Th2-like response.
利用STAT6基因敲除的BALB/c小鼠，我们分析了由STAT6诱导的Th2反应在决定由蠕虫寄生虫肥胖带绦虫引起的小鼠囊尾蚴病结局中的作用。在感染肥胖带绦虫后，野生型BALB/c小鼠产生了强烈的Th2样反应；产生了高水平的IgG1、IgE、IL-4以及IL-13；并且仍然易受肥胖带绦虫感染。相比之下，同样受到感染的STAT6基因敲除小鼠产生了强烈的Th1样反应；产生了高水平的IgG2a、IL-12、IFN-γ以及一氧化氮；并且有效地控制了肥胖带绦虫感染。这些发现表明，通过STAT6介导的信号通路诱导的Th2样反应介导了对肥胖带绦虫的易感性，此外，与大多数蠕虫的情况不同，针对肥胖带绦虫的免疫是由Th1样反应而非Th2样反应介导的。
