Terrazas L I, Cruz M, Rodríguez-Sosa M, Bojalil R, García-Tamayo F, Larralde C
Department of Biology, Facultad de Química, Universidad Nacional Autónoma de México, México D.F.
Parasitol Res. 1999 Feb;85(2):135-41. doi: 10.1007/s004360050522.
Resistance and susceptibility to different parasitic diseases have been associated with the predominance of Th1- or Th2-type immune responses. In experimental murine cysticercosis a Th1 response seems to be involved in resistance, whereas Th2 activity is associated with heavy parasite intensities. To test this notion the roles of Th1- and Th2-type cytokines in infected mice were studied after treatment with anticytokine monoclonal antibodies or with recombinant murine cytokines during early stages of infection. Mice receiving anti-interleukin 10 (IL-10) carried lower parasite intensities than did control mice and developed a strong Th1-type response, whereas mice receiving anti-interferon gamma (IFN-gamma) showed a dramatic increase in susceptibility. Treatment with recombinant cytokines confirmed these results; mice receiving IFN-gamma and IL-2 showed low parasite numbers, whereas IL-10 induced a significant increase in parasite loads. Thus, the Th1-type immune response plays a fundamental role in protection against Taenia crassiceps cysticercosis, whereas Th2, at least through IL-10, favors parasite establishment.
对不同寄生虫病的抗性和易感性与Th1型或Th2型免疫反应的优势有关。在实验性小鼠囊尾蚴病中，Th1反应似乎与抗性有关，而Th2活性与高寄生虫感染强度有关。为了验证这一观点，在感染早期用抗细胞因子单克隆抗体或重组鼠细胞因子处理感染小鼠后，研究了Th1型和Th2型细胞因子在感染小鼠中的作用。接受抗白细胞介素10（IL-10）的小鼠寄生虫感染强度低于对照小鼠，并产生强烈的Th1型反应，而接受抗干扰素γ（IFN-γ）的小鼠易感性显著增加。用重组细胞因子处理证实了这些结果；接受IFN-γ和IL-2的小鼠寄生虫数量较低，而IL-10则导致寄生虫负荷显著增加。因此，Th1型免疫反应在抵抗肥胖带绦虫囊尾蚴病中起重要作用，而Th2至少通过IL-10促进寄生虫的寄生。
