前沿：对由α-半乳糖神经酰胺脉冲处理的单核细胞衍生树突状细胞激活的人Vα24 + CD8 +自然杀伤T细胞的分析

Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated by alpha-galactosylceramide-pulsed monocyte-derived dendritic cells.

作者信息

Takahashi Tsuyoshi, Chiba Shigeru, Nieda Mie, Azuma Takeshi, Ishihara Soichiro, Shibata Yoichi, Juji Takeo, Hirai Hisamaru

机构信息

Department of Hematology, University of Tokyo, Japan.

出版信息

J Immunol. 2002 Apr 1;168(7):3140-4. doi: 10.4049/jimmunol.168.7.3140.

DOI:10.4049/jimmunol.168.7.3140

PMID:11907064

Abstract

Human Valpha24(+) NKT cells constitute a counterpart of mouse Valpha14(+) NKT cells, both of which use an invariant TCR-alpha chain. The human Valpha24(+) NKT cells as well as mouse Valpha14(+) NKT cells are activated by glycolipids in a CD1d-restricted manner and produce many immunomodulatory cytokines, possibly affecting the immune balance. In mice, it has been considered from extensive investigations that Valpha14(+)CD8(+) NKT cells that express invariant TCR do not exist. Here we introduce human Valpha24(+)CD8(+) NKT cells. These cells share important features of Valpha24(+) NKT cells in common, but in contrast to CD4(-)CD8(-) (double-negative) or CD4(+) Valpha24(+) NKT cells, they do not produce IL-4. Our discovery may extend and deepen the research field of Valpha24(+) NKT cells as well as help to understand the mechanism of the immune balance-related diseases.

摘要

人类Vα24(+) NKT细胞构成了小鼠Vα14(+) NKT细胞的对应物，两者均使用恒定的TCR-α链。人类Vα24(+) NKT细胞以及小鼠Vα14(+) NKT细胞以CD1d限制性方式被糖脂激活，并产生许多免疫调节细胞因子，可能影响免疫平衡。在小鼠中，通过广泛研究认为不存在表达恒定TCR的Vα14(+)CD8(+) NKT细胞。在此我们介绍人类Vα24(+)CD8(+) NKT细胞。这些细胞具有Vα24(+) NKT细胞的共同重要特征，但与CD4(-)CD8(-)（双阴性）或CD4(+) Vα24(+) NKT细胞不同，它们不产生IL-4。我们的发现可能会扩展和深化Vα24(+) NKT细胞的研究领域，并有助于理解免疫平衡相关疾病的机制。