Karcioglu Zeynel A, Abboud Emad B, Al-Mesfer Saleh A, Al-Rashed Waleed, Pilapil Delia H
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
J AAPOS. 2002 Feb;6(1):26-32. doi: 10.1067/mpa.2002.120643.
Retinoblastoma (RB) is known to present with atypical signs and symptoms in older patients. Our article reviews the clinical and histopathological features of RB encountered in children older than 5 years of age.
A total of 337 consecutive patients with RB were reviewed. Eighteen (5.3%; 10 males, 8 females) who presented after the age of 5 were selected for further analysis of clinical data and histopathological material in this retrospective, non-comparative case series.
The age range was from 5 to 12 years (mean age 6.4). Unilateral disease was seen in 14 children, bilateral disease in 4 children. Eleven children were the product of consanguineous marriages. Seven patients had leukocoria; the others presented with signs of uveitis, cellulitis, and/or trauma. Three patients had flat, plaque-like lesions on histopathologic evaluation.
Clinical and histopathologic features were atypical in 47% and 21% respectively in the retinoblastoma patients who presented after the age of 5 years.
视网膜母细胞瘤（RB）在年长患者中常表现出非典型的体征和症状。我们的文章回顾了5岁以上儿童RB的临床和组织病理学特征。
回顾了337例连续性RB患者。在这个回顾性、非对照病例系列中，选择了18例（5.3%；10例男性，8例女性）5岁以后发病的患者进行临床资料和组织病理学材料的进一步分析。
年龄范围为5至12岁（平均年龄6.4岁）。14例儿童为单眼发病，4例为双眼发病。11例儿童为近亲结婚后代。7例患者有白瞳症；其他患者表现为葡萄膜炎、蜂窝织炎和/或外伤体征。3例患者经组织病理学评估有扁平的斑块样病变。
5岁以后发病的视网膜母细胞瘤患者中，临床和组织病理学特征分别有47%和21%为非典型表现。
