Hoekstra Arend, Elstrodt Jan M, Nikkels Peter G J, Tiebosch Anton T M G
Bio-Medical Technology Center, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Cardiovasc Intervent Radiol. 2002 Jan-Feb;25(1):53-6. doi: 10.1007/s00270-001-0054-2. Epub 2002 Jan 18.
To evaluate the interaction between the Cordis Keeper vena caval filter and vessel wall in a porcine model.
Implantation of the filter was performed in five pigs. Radiologic data concerning inferior vena cava (IVC) diameter and filter patency, filter leg span, and stability were collected. At 2 or 6 months post-implantation, histopathologic analysis of the IVC wall was performed.
All filters remained patent with no evidence of migration. However, at 6 months follow-up, two legs of one filter penetrated the vessel wall and were adherent to the liver. These preliminary results suggest that with the observed gradual increase in the filter span, the risk of caval wall penetration increases with time, especially in a relatively small IVC (average diameter 16 mm).
The Cordis Keeper filter was well tolerated, but seems to be prone to caval wall penetration in the long term.
在猪模型中评估科迪斯滤器（Cordis Keeper）与血管壁之间的相互作用。
对五头猪植入该滤器。收集有关下腔静脉（IVC）直径、滤器通畅情况、滤器腿跨度和稳定性的放射学数据。在植入后2个月或6个月，对下腔静脉壁进行组织病理学分析。
所有滤器均保持通畅，无移位迹象。然而，在6个月的随访中，一个滤器的两条腿穿透了血管壁并附着于肝脏。这些初步结果表明，随着观察到的滤器跨度逐渐增加，腔壁穿透的风险随时间增加，尤其是在相对较小的下腔静脉（平均直径16毫米）中。
科迪斯滤器耐受性良好，但从长期来看似乎易于发生腔壁穿透。
