Wenger J J, Osborne M W
Arch Int Pharmacodyn Ther. 1975 Oct;217(2):251-6.
The apparent decrease in myocardial force of contraction observed after L-dopa, 10 mg/kg i.v., is artifactual since the maximum rate of left venticular isovolumic pressure rise (dP/dt) remains elevated. The apparent decrease is due to shrinkage in heart size secondary to venous "pooling". The decrease in contractile force parallels a decrease in cardiac output. A peripheral decarboxylase inhibitor and L-dopa produce a decrease in both contractile force and dP/dt. Strain gauge arch recordings may produce false-positive data during marked venous pooling.
静脉注射10mg/kg左旋多巴后观察到的心肌收缩力明显下降是人为造成的，因为左心室等容压力上升的最大速率（dP/dt）仍保持升高。这种明显的下降是由于静脉“ pooling”继发的心脏大小缩小所致。收缩力的下降与心输出量的下降平行。外周脱羧酶抑制剂和左旋多巴会使收缩力和dP/dt均下降。在明显的静脉pooling期间，应变片拱形记录可能会产生假阳性数据。
