Wauquier A, Niemegeers C J
Arch Int Pharmacodyn Ther. 1975 Oct;217(2):280-92.
Pimozide (0.04, 0.16, 0.63 and 2.50 mg/kg), haloperidol (0.01, 0.04, 0.16 and 0.63 mg/kg) and pipamperone (2.50, 10.0, 40.0 and 160 mg/kg) were given subcutaneously to rats, pressing a lever for brain-stimulation through electrodes implanted in the lateral hypothalamic region of the medial forebrain bundle. The lowest dose of each neuroleptic did not affect self-stimulation; the second dose inhibited the response rate by approximately 50%, whereas the two highest doses completely suppressed self-stimulation behaviour. The centrally acting anticholinergic dexetimide (0.63 mg/kg, s.c.) completly antagonized the pimozide-induced inhibition; the haloperidol-induced inhibition was also completely antagonized except at its highest doses, whereas the effects of the sedative neuroleptic pipamperone were not antagonized. These data are consistent with a presumed dopaminergic cholinergic striatal interaction and show brain self-stimulation to be an effective measure of neuroleptic-anticholinergic interaction.
将匹莫齐特（0.04、0.16、0.63和2.50毫克/千克）、氟哌啶醇（0.01、0.04、0.16和0.63毫克/千克）和匹泮哌隆（2.50、10.0、40.0和160毫克/千克）皮下注射给大鼠，大鼠通过植入内侧前脑束下丘脑外侧区的电极按压杠杆以进行脑刺激。每种抗精神病药物的最低剂量不影响自我刺激；第二剂量使反应率降低约50%，而两个最高剂量则完全抑制自我刺激行为。中枢性抗胆碱能药物右苯甲酰芽子碱（0.63毫克/千克，皮下注射）完全拮抗了匹莫齐特诱导的抑制作用；氟哌啶醇诱导的抑制作用除最高剂量外也完全被拮抗，而镇静性抗精神病药物匹泮哌隆的作用未被拮抗。这些数据与推测的多巴胺能-胆碱能纹状体相互作用一致，并表明脑自我刺激是抗精神病药物-抗胆碱能相互作用的一种有效测量方法。
