Wauquier A, Niemegeers C J
Arch Int Pharmacodyn Ther. 1979 Jun;239(2):230-40.
Rats implanted with an electrode in the lateral hypothalamus were trained to obtain brain-stimulation by either pressing a lever or by licking a steel drinking tube in subsequent 15-min sessions. Half of the rats began the sessions with lever-pressing, the other half began with licking. After stabilization of the response rates, rats were run in saline- or drug-sessions. During the drug sessions rats were treated with 4 doses of the following neuroleptics: haloperidol, pimozide, pipamperone, azaperone. These neuroleptics dose-relatedly inhibited licking for brain-stimulation but suppressed lever-pressing only at the highest dose tested. The lick response was thus inhibited at lower doses than lever-pressing. This differential sensitivity to neuroleptics appears not to be due to a difference in baseline response rates, schedule differences or to the motor activity involved in both responses, but rather to the different thresholds of reinforcement produced by licking and lever-pressing for brain-stimulation.
在外侧下丘脑植入电极的大鼠，在随后15分钟的实验环节中，通过按压杠杆或舔舐一根钢制饮水管来训练获取脑刺激。一半大鼠从按压杠杆开始实验环节，另一半从舔舐开始。在反应率稳定后，大鼠进行生理盐水或药物实验环节。在药物实验环节，给大鼠使用以下4种剂量的抗精神病药物：氟哌啶醇、匹莫齐特、哌泊噻嗪、阿扎哌隆。这些抗精神病药物与剂量相关地抑制了为获取脑刺激而进行的舔舐行为，但仅在测试的最高剂量下抑制了按压杠杆行为。因此，舔舐反应在比按压杠杆更低的剂量下就受到了抑制。这种对抗精神病药物的不同敏感性似乎不是由于基线反应率的差异、实验安排的差异或两种反应中涉及的运动活动差异，而是由于舔舐和按压杠杆获取脑刺激所产生的不同强化阈值。
