新型噻嗪烷和噻唑烷肽核酸单体：合成、掺入肽核酸及杂交研究。
New thiazane and thiazolidine PNA monomers: synthesis, incorporation into PNAs and hybridization studies.
作者信息
Bregant Sarah, Burlina Fabienne, Chassaing Gérard
机构信息
Laboratoire de Chimie Organique Biologique, Université P. et M. Curie, CNRS-UMR 7613, 4 place Jussieu, 75252 Paris Cedex 05, France.
出版信息
Bioorg Med Chem Lett. 2002 Apr 8;12(7):1047-50. doi: 10.1016/s0960-894x(02)00076-8.
Abstract
New constrained PNA monomers containing a substituted thiazolidine or a thiazane ring were synthesized and incorporated in the center of a 9-mer homothymine PNA. The PNA/DNA hybrids stability was studied by UV-melting experiments which showed that the presence of the modified unit destabilizes the PNA/DNA triplexes.
摘要
合成了含有取代噻唑烷或硫氮杂环戊烷环的新型受限肽核酸单体，并将其掺入9聚体同型胸腺嘧啶肽核酸的中心。通过紫外熔解实验研究了肽核酸/DNA杂交体的稳定性，结果表明修饰单元的存在会使肽核酸/DNA三链体不稳定。
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