Rani P Juliet Arockia, Panneerselvam C
Department of Medical Biochemistry, Dr. Alagappa Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India.
J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):B134-7. doi: 10.1093/gerona/57.4.b134.
The effect of L-carnitine on lipid peroxidation and enzymatic antioxidants, such as superoxide dismutase, catalase, and glutathione peroxidase, was evaluated in brain regions of young and old rats. In all brain regions except the hypothalamus, lipid peroxidation was higher for old rats than for young control rats. The activity of superoxide dismutase, glutathione peroxidase, and catalase was lower in the striatum, cerebral cortex, and hippocampus, but no difference was observed in the hypothalamus and cerebellum. L-Carnitine administration (intraperitoneally) prevented thiobarbituric acid-reactive substance formation in the cerebral cortex, cerebellum, hypothalamus, hippocampus, and striatum of 24-month-old rats. Administration of L-carnitine reversed the age-associated changes in a duration-dependent manner. Results suggest that the neuroprotective effect on the brains in old rats was achieved by the elevation of antioxidants with L-carnitine.
在年轻和老年大鼠的脑区中评估了左旋肉碱对脂质过氧化以及超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等酶促抗氧化剂的影响。除下丘脑外，在所有脑区中，老年大鼠的脂质过氧化水平均高于年轻对照大鼠。超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶的活性在纹状体、大脑皮层和海马体中较低，但在下丘脑和小脑中未观察到差异。腹腔注射左旋肉碱可防止24月龄大鼠大脑皮层、小脑、下丘脑、海马体和纹状体中硫代巴比妥酸反应性物质的形成。左旋肉碱的给药以时间依赖性方式逆转了与年龄相关的变化。结果表明，左旋肉碱通过提高抗氧化剂水平对老年大鼠的大脑起到了神经保护作用。
