Rees M, Hague S, Oehler M K, Bicknell R
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Climacteric. 1999 Mar;2(1):52-8. doi: 10.3109/13697139909025563.
Bleeding problems are the most common reason for discontinuation of hormone replacement therapy. Human endometrium undergoes the unique process of benign angiogenesis under the control of ovarian steroids during reproductive life and it is presumed that similar processes occur when women take hormone replacement therapy. The key players in endometrial growth and angiogenesis are vascular endothelial growth factor, thymidine phosphorylase and adrenomedullin. Regulation of these angiogenic factors is described.
出血问题是停止激素替代疗法的最常见原因。在生殖期，人类子宫内膜在卵巢甾体激素的控制下经历良性血管生成这一独特过程，据推测，女性接受激素替代疗法时会发生类似过程。血管内皮生长因子、胸苷磷酸化酶和肾上腺髓质素是子宫内膜生长和血管生成的关键因素。本文描述了这些血管生成因子的调控。
