使用手性亚砜配体的路易斯酸催化不对称狄尔斯-阿尔德反应：手性2-(芳基亚磺酰基甲基)-1,3-恶唑啉衍生物
Lewis acid-catalyzed asymmetric diels-alder reactions using chiral sulfoxide ligands: chiral 2-(arylsulfinylmethyl)-1,3-oxazoline derivatives.
作者信息
Watanabe Kazuhiro, Hirasawa Takashi, Hiroi Kunio
机构信息
Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2002 Mar;50(3):372-9. doi: 10.1248/cpb.50.372.
PMID:11911201
Abstract
New chiral sulfoxide-1,3-oxazoline ligands have been developed as chiral ligands for Lewis acid-catalyzed asymmetric Diels-Alder reactions. The use of chiral sulfinyl 1,3-oxazoline ligands in copper(II)-catalyzed asymmetric Diels-Alder reactions provided an endo cycloadduct as a major product with moderate enantioselectivity. A rationale is proposed for the mechanism of the asymmetric induction.
摘要
新型手性亚砜-1,3-恶唑啉配体已被开发用作路易斯酸催化的不对称狄尔斯-阿尔德反应的手性配体。在手性亚磺酰基1,3-恶唑啉配体用于铜（II）催化的不对称狄尔斯-阿尔德反应中，以内型环加成产物作为主要产物，对映选择性适中。针对不对称诱导机理提出了一种理论依据。
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