Uno T, Kawakami H, Funami Y, Isobe K, Yasuda S, Aruga T, Shimada H, Okazumi S, Nabeya Y, Mastubara H, Ochiai T, Ito H
Department of Radiation Oncology, Chiba University Gradnate School, Japan.
Anticancer Res. 2001 Nov-Dec;21(6A):4095-7.
The objectives of this study were to evaluate the efficacy and toxicity of concurrent chemoradiation in patients with esophageal cancer aged 80 and older.
Seven patients with esophageal cancer, aged 80 or more were treated with chemoradiation. Five received a systemic combination of cisplatin and 5-fluorouracil while 2 received daily 5-fluorouracil, concurrent with radiotherapy. The total doses of radiotherapy ranged from 50 to 65 Gy.
Complete response was obtained in 3 patients, and partial response and no change in 2 cases each. Esophageal passage improved in 4 patients. The treatment was well-tolerated. There was no death attributable to any adverse treatment effects. None of the patients experienced grade 3 or worse acute toxicities.
This study demonstrated that advanced age per se is not a sufficient reason to exclude elderly patients from aggressive treatment.
本研究的目的是评估80岁及以上食管癌患者同步放化疗的疗效和毒性。
7例80岁及以上的食管癌患者接受了放化疗。5例患者接受顺铂和5-氟尿嘧啶的全身联合化疗，2例患者接受每日5-氟尿嘧啶并同步放疗。放疗总剂量为50至65 Gy。
3例患者获得完全缓解，2例患者部分缓解，2例患者病情无变化。4例患者食管通畅情况改善。治疗耐受性良好。没有因任何不良治疗效应导致的死亡。没有患者出现3级或更严重的急性毒性反应。
本研究表明，高龄本身并不是将老年患者排除在积极治疗之外的充分理由。
