紫外线照射的哺乳动物细胞中DNA的复制后修复

Postreplication repair of DNA in UV-irradiated mammalian cells.

作者信息

Lehmann A R

出版信息

Basic Life Sci. 1975;5B:617-23. doi: 10.1007/978-1-4684-2898-8_31.

PMID:1191182

Abstract

Some current controversies concerning the mechanism of postreplication repair in mammalian cells are discussed. We have found that two xeroderma pigmentosum cell lines normal in excision-repair are abnormal in postreplication repair. The rate of postreplication repair is slower than that in normal cells and is caffeine sensitive. In normal human fibroblasts, caffeine has little effect.

摘要

本文讨论了当前关于哺乳动物细胞复制后修复机制的一些争议。我们发现，两种切除修复正常的着色性干皮病细胞系在复制后修复方面存在异常。其复制后修复速率比正常细胞慢，且对咖啡因敏感。在正常人成纤维细胞中，咖啡因几乎没有影响。