Prisant L Michael, Resnick Lawrence M, Hollenberg Steven M, Jupin Dena
Section of Cardiology, Medical College of Georgia, Augusta 30912-3105, USA.
Ethn Dis. 2002 Winter;12(1):63-8.
To determine arterial elasticity in normotensives and in treated and untreated hypertensive Black and White subjects.
A prospective multicenter, controlled clinical trial evaluated large (C-) and small (C2) artery elasticity indices among 3 groups: 1) normotensive subjects with or without a family history of hypertension; 2) controlled and treated hypertensive subjects; and 3) untreated and uncontrolled hypertensive subjects. Blood pressure was measured using a mercury manometer and arterial compliance or elasticity was determined using a CVProfilor DO-2020 CardioVascular Profiling System (Hypertension Diagnostics, Inc, Eagan, Minn). These parameters were measured in triplicate 3 minutes apart in a random sequence, with the patient in a supine position. Two-way ANOVA was used for statistical evaluation.
One hundred seventy eight subjects met stratification and enrollment criteria. The mean age was 46 years. 109 were White and 69 were Black. [table: see text]
Small and large arterial elasticity indices are reduced as hypertension status worsens. Age and height were important covariates of C1 and C2. Race was not found to be a significant predictor of either C1 or C2. Large and small artery elasticity indices do not differ between White and Black subjects with varying degrees of hypertension after adjusting for covariates. More studies with a larger number of subjects are required.
测定血压正常者以及接受治疗和未接受治疗的高血压黑人和白人受试者的动脉弹性。
一项前瞻性多中心对照临床试验评估了3组人群的大动脉（C -）和小动脉（C2）弹性指数：1）有或无高血压家族史的血压正常者；2）血压得到控制且接受治疗的高血压患者；3）未接受治疗且血压未得到控制的高血压患者。使用汞柱式血压计测量血压，并使用CVProfilor DO - 2020心血管分析系统（高血压诊断公司，明尼苏达州伊根）测定动脉顺应性或弹性。这些参数在患者仰卧位时以随机顺序每隔3分钟测量3次。采用双向方差分析进行统计学评估。
178名受试者符合分层和入选标准。平均年龄为46岁。其中109人为白人，69人为黑人。[表格：见正文]
随着高血压病情加重，小动脉和大动脉弹性指数降低。年龄和身高是C1和C2的重要协变量。未发现种族是C1或C2的显著预测因素。在对协变量进行校正后，不同程度高血压的白人和黑人受试者之间的大动脉和小动脉弹性指数没有差异。需要开展更多纳入受试者数量更多的研究。
