Adams C W, Knox J, Morgan R S
Atherosclerosis. 1975 Sep-Oct;22(2):229-40. doi: 10.1016/0021-9150(75)90005-2.
Physicochemical exchange of radioactive cholesterol was investigated in mildly hypercholesterolaemic rabbits. Such exchange was examined in erythrocytes and atheroma lipids in situ in the aortic wall and in such lipids when implanted subcutaneously. The implanted atheroma lipids gained radioactivity from intravenously injected [3H]cholesterol, even though cholesterol was being resorbed from the implants. Autoradiography showed exchange between plasma cholesterol and both intracellular and dispersed extracellular lipid in these implants. Cholesterol crystals in both implants and atheromatous lesions labelled only sluggishly. The results are consistent with the view that physicochemical exchange is a major factor in cholesterol movement in vivo.
在轻度高胆固醇血症兔中研究了放射性胆固醇的物理化学交换。在红细胞、主动脉壁原位动脉粥样硬化脂质以及皮下植入的此类脂质中检测了这种交换。尽管胆固醇正从植入物中被吸收，但植入的动脉粥样硬化脂质从静脉注射的[3H]胆固醇中获得了放射性。放射自显影显示血浆胆固醇与这些植入物中的细胞内脂质和分散的细胞外脂质之间存在交换。植入物和动脉粥样硬化病变中的胆固醇晶体标记缓慢。这些结果与物理化学交换是体内胆固醇移动的主要因素这一观点一致。
