Judd J T, Wexler B C
Atherosclerosis. 1975 Sep-Oct;22(2):241-56. doi: 10.1016/0021-9150(75)90006-4.
The relation of lactation and weaning to the development of early arterial lesions in the female breeder rat was investigated. Changes in aortic hexosamine and 35S-uptake, which are indicative of ground substance metabolism were correlated with changes in aortic calcium, phosphorus, and 45Ca-uptake during lactation and weaning. Lactation was associated with reduced aortic hexosamine content and lowered uptake of [S]sulfate. Further dynamic changes in aortic metabolism of these substances occurred following weaning in conjunction with an intense calcium uptake in the aorta of some, but not all, of the post-lactation animals. These latter changes were associated with the beginning aortic calcifications. Histopathologically, early arterial lesions developing during lactation, consist of intimal accumulations of mucopolysaccharide capped over by collagen. With repeated breeding cycles, these early lesions become exacerbated with extensive medial calcification occurring in areas rich in mucopolysaccharide and collagen particularly around degenerating elastic fibers. The hormones associated with reproduction and lactation may have a conditioning effect on these arterial connective tissue alterations and the development of arterial degenerative changes.
研究了哺乳期和断奶与雌性繁殖大鼠早期动脉病变发展的关系。作为基质代谢指标的主动脉己糖胺和35S摄取量的变化，与哺乳期和断奶期间主动脉钙、磷和45Ca摄取量的变化相关。哺乳期与主动脉己糖胺含量降低和[S]硫酸盐摄取量降低有关。断奶后，这些物质在主动脉中的代谢进一步发生动态变化，同时部分（而非全部）哺乳后动物的主动脉出现强烈的钙摄取。后一种变化与主动脉钙化的开始有关。组织病理学上，哺乳期出现的早期动脉病变由内膜粘多糖积聚组成，其表面覆盖有胶原蛋白。随着繁殖周期的重复，这些早期病变会加剧，在富含粘多糖和胶原蛋白的区域，特别是在退化的弹性纤维周围，会出现广泛的中膜钙化。与生殖和泌乳相关的激素可能对这些动脉结缔组织改变和动脉退行性变化的发展具有调节作用。
