Wexler B C
Paroi Arterielle. 1981;7(4):143-53.
Multiparous Sprague-Dawley rats were killed at 7, 14, and 21 days of gestation, at parturition, after 7, 14 and 21 days of lactation, and at 7 and 14 days post-weaning of their fourth reproductive cycle. Grossly visible aortic sclerosis appeared and became progressively more severe during gestation, parturition, and early lactation. Although some of the female breeders had no detectable, grossly-visible aortic sclerosis, all of the 4-time breeders had microscopic aortic sclerosis. Progressive deterioration of the aortic elastic tissue and ground substance was particularly prevalent during the gestation and lactation phases. Calcification and cartilaginous metaplasia appeared during the post-weaning phase. Virgin control rats, equal in age to the 4-time breeders, were completely free of arterial disease. It is believed that abnormal activity of the hypothalamic-pituitary-adrenal axis in association with repeated breeding conditions these animals toward premature arteriosclerosis.
经产斯普拉格-道利大鼠在妊娠7天、14天和21天、分娩时、哺乳7天、14天和21天后以及其第四个生殖周期断奶后7天和14天被处死。在妊娠、分娩和哺乳早期，肉眼可见的主动脉硬化出现并逐渐加重。虽然一些雌性繁殖大鼠没有可检测到的肉眼可见的主动脉硬化，但所有4次繁殖的大鼠都有微观主动脉硬化。主动脉弹性组织和基质的进行性退化在妊娠和哺乳阶段尤为普遍。钙化和软骨化生在断奶后阶段出现。年龄与4次繁殖大鼠相同的未交配对照大鼠完全没有动脉疾病。据信，下丘脑-垂体-肾上腺轴的异常活动与反复繁殖使这些动物易患过早动脉硬化有关。
