Vogelberg K H, Berchtold P, Berger H, Gries F A, Klinger H, Kübler W, Stolze T
Atherosclerosis. 1975 Sep-Oct;22(2):271-85. doi: 10.1016/0021-9150(75)90008-8.
In a controlled study on 121 patients with peripheral vascular disease (PVD) (75 patients with primary hyperlipoproteinemia, 15 diabetics, 31 patients without metabolic disease) the relationship between risk factors (hyperlipoproteinemia, obesity, hypertension, abnormal glucose tolerance, smoking) and the degree and localisation of sclerotic lesions was investigated by angiography. The degree was directly related in all patients to the number of risk factors, in Type IIa to cholesterol levels, in diabetics and Type IV with abnormal glucose tolerance to age. The latter patients were 5-10 years older than patients with Type IIa and showed 2 or more additional risk factors. The sclerotic lesions affected in Type IIa, less in Type IIb, predominately the pelvic vessels. Diabetics and Type IV patients showed a distal arterial involvement. The difference was significant. The degree of sclerotic lesions in arteries of the pelvis and the distal lower limb was positively correlated with the cholesterol-triglyceride ratio. Smoking aggravated the pelvic lesions in Type IV. Hypertension lead to more pronounced lesions of the distal lower limb in Type II. S-shaped tortuosities of the big vessels were shown to be typical, independent of localisation or degree.
在一项针对121例周围血管疾病（PVD）患者的对照研究中（75例原发性高脂血症患者、15例糖尿病患者、31例无代谢疾病患者），通过血管造影术研究了危险因素（高脂血症、肥胖、高血压、糖耐量异常、吸烟）与硬化病变的程度和部位之间的关系。在所有患者中，病变程度与危险因素的数量直接相关；在IIa型患者中与胆固醇水平相关；在糖尿病患者以及糖耐量异常的IV型患者中与年龄相关。后一组患者比IIa型患者大5至10岁，且显示出另外2种或更多的危险因素。硬化病变在IIa型患者中受累，在IIb型患者中较少，主要累及盆腔血管。糖尿病患者和IV型患者显示出远端动脉受累。差异具有显著性。盆腔和下肢远端动脉的硬化病变程度与胆固醇-甘油三酯比值呈正相关。吸烟会加重IV型患者的盆腔病变。高血压会导致II型患者下肢远端病变更明显。大血管呈S形扭曲被证明是典型的，与部位或程度无关。
