Fellin C G, Briani G, Baggio G, Manzato E, Veronese R
Atherosclerosis. 1977 Apr;26(4):593-602. doi: 10.1016/0021-9150(77)90126-5.
The prevalence of coronary artery disease (CAD) and peripheral artery disease (PAD) was studied in 280 (203 males, 77 females) patients with different types of primary hyperlipoproteinemia. In primary hyperbetalipoproteinemia the prevalence of CAD (45% for Type IIa and 47% for Type IIb) is significatly higher than that in the other types of hyperlipoproteinemia (38% for Type IV and 17% for Type V). On the other hand, PAD prevalence is much higher in hypertriglyceridemia (21% in Type IIb and 20% in Type V) than in hypercholesterolemia alone (9% in Type IIa). These results suggest ths atherosclerotic complications are concerned. Moreover, the high frequency of PAD found in hypertriglyceridemia can be related to the high occurrence of diabetes in these patients. The effects of other major risk factors of atherosclerosis (smoking and hypertension) were also evaluated. Our results indicate that the association of hypercholestolemia and hypertension is more dangerous than the co-occurence of hypercholesterolemia and smoking.
对280例（203例男性，77例女性）不同类型原发性高脂血症患者的冠状动脉疾病（CAD）和外周动脉疾病（PAD）患病率进行了研究。在原发性高β脂蛋白血症中，CAD的患病率（IIa型为45%，IIb型为47%）显著高于其他类型的高脂血症（IV型为38%，V型为17%）。另一方面，高甘油三酯血症患者的PAD患病率（IIb型为21%，V型为20%）远高于单纯高胆固醇血症患者（IIa型为9%）。这些结果提示存在动脉粥样硬化并发症。此外，高甘油三酯血症患者中PAD的高发生率可能与这些患者中糖尿病的高发病率有关。还评估了动脉粥样硬化其他主要危险因素（吸烟和高血压）的影响。我们的结果表明，高胆固醇血症与高血压并存比高胆固醇血症与吸烟并存更危险。
