Chandie Shaw P K, Vandenbroucke J P, Tjandra Y I, Rosendaal F R, Rosman J B, Geerlings W, de Charro F Th, van Es L A
Department of Nephrology, C3-P, Leiden University Medical Center, Leiden, The Netherlands.
Diabetologia. 2002 Mar;45(3):337-41. doi: 10.1007/s00125-001-0758-5.
AIMS/HYPOTHESIS: We aimed to investigate the risk of end-stage diabetic nephropathy due to Type II (non-insulin-dependent) diabetes mellitus in Indo-Asian immigrants from Surinam.
A demographically based case-control study was carried out in Surinamese Indo-Asian immigrants and Dutch Caucasian subjects. All patients with end-stage diabetic nephropathy who had started dialysis between 1990 and 1998 were identified through a national registry of all patients entering a renal replacement program in the Netherlands. The general population of native Dutch and Surinamese Indo-Asians were considered the control subjects.
Among Indo-Asian immigrants, the age adjusted relative risk of end-stage diabetic nephropathy was 38 (95 % CI 16 to 91) compared with the native Dutch population. The duration of diabetes until the start of dialysis treatment was similar in both ethnic groups, about 17 years.
CONCLUSION/INTERPRETATION: The Indo-Asian subjects had a nearly 40-fold increase in the risk for end-stage diabetic nephropathy due to Type II diabetes, compared with the native Dutch population. This was higher than expected on the basis of the eightfold higher prevalence of diabetes in the Indo-Asian population. The similar duration of diabetes until the start of dialysis treatment in both ethnic groups supports the hypothesis of a higher incidence of diabetic nephropathy in the Indo-Asian diabetic population. Early and frequent screening for diabetes and microalbuminuria is recommended in Indo-Asian subjects.
目的/假设：我们旨在调查苏里南印度裔亚洲移民中因II型（非胰岛素依赖型）糖尿病导致终末期糖尿病肾病的风险。
在苏里南印度裔亚洲移民和荷兰白种人受试者中开展了一项基于人口统计学的病例对照研究。通过荷兰所有进入肾脏替代治疗项目患者的国家登记系统，确定了1990年至1998年间开始透析的所有终末期糖尿病肾病患者。荷兰本土人和苏里南印度裔亚洲人的普通人群被视为对照受试者。
与荷兰本土人群相比，印度裔亚洲移民中终末期糖尿病肾病的年龄调整相对风险为38（95%置信区间16至91）。两个种族群体中直至开始透析治疗的糖尿病病程相似，约为17年。
结论/解读：与荷兰本土人群相比，印度裔亚洲受试者因II型糖尿病导致终末期糖尿病肾病的风险增加了近40倍。这高于基于印度裔亚洲人群中糖尿病患病率高出八倍所预期的风险。两个种族群体中直至开始透析治疗的糖尿病病程相似，这支持了印度裔亚洲糖尿病患者中糖尿病肾病发病率较高的假设。建议对印度裔亚洲受试者进行早期且频繁的糖尿病和微量白蛋白尿筛查。
