Ishiguro Kyoko, Nagata Satoko, Oku Hisae, Yamaki Masae
School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien Kyuban-cho, Hyogo, Japan.
Planta Med. 2002 Mar;68(3):258-61. doi: 10.1055/s-2002-23125.
The CHCl3-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.
