Department of Natural Medicine, School of Pharmacy, Shanghai Engineering Research Center of Immuno Therapeutics, Fudan University, 826 Zhangheng Road, Zhangjiang Pudong, Shanghai, 201203, China.
School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Prog Chem Org Nat Prod. 2020;112:85-182. doi: 10.1007/978-3-030-52966-6_2.
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects. A detailed account of the chemical constituents, including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids, is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects.
贯叶金丝桃属（Hypericum L.）是金丝桃科（Hypericaceae）中的一个双子叶植物属。贯叶金丝桃属植物的成分因其重要的生物特性而备受重视。在主要文献和民族植物学报告中都有记载，贯叶金丝桃属植物被用于治疗抑郁症和作为抗菌剂。本综述全面总结了贯叶金丝桃属植物的化学成分及其生物活性。详细描述了化学成分，包括间苯三酚衍生物、黄烷酮、二蒽酮和类黄酮。这些化合物表现出多种生物活性，包括抗菌、细胞毒性、抗抑郁样和抗伤害感受作用。
