Umemura Takeji, Alter Harvey J, Tanaka Eiji, Orii Koji, Yeo Anthony E t, Shih J Wai-Kuo, Matsumoto Akihiro, Yoshizawa Kaname, Kiyosawa Kendo
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Hepatology. 2002 Apr;35(4):953-9. doi: 10.1053/jhep.2002.32536.
The SEN virus (SENV) is a recently identified single-stranded, circular DNA virus. A strong association between 2 SENV variants (SENV-D and SENV-H) and transfusion-associated non-A-to-E hepatitis has been reported. To clarify the effect of SENV infection on coexisting chronic hepatitis C and the effect of interferon alfa (IFN-alpha) therapy on SENV replication, SENV DNA was quantitated by polymerase chain reaction in serum samples from 186 patients with chronic hepatitis C. Thirty-nine of 186 (21%) patients with chronic hepatitis C were positive for SENV DNA. There were no differences in the clinical, virologic and histologic features between patients with and without SENV infection. Eighteen of 102 patients with chronic hepatitis C who received IFN-alpha were positive for SENV DNA. The sustained response rate for hepatitis C virus (HCV) clearance after IFN-alpha treatment did not differ significantly between patients with SENV (28%) and without SENV infection (39%). SENV DNA levels decreased during therapy in 15 of 16 patients, and 11 of the 16 patients (69%) had a sustained loss of SENV DNA in response to IFN-alpha. In coinfected patients, SENV responses to IFN-alpha were significantly better in those who failed to clear HCV RNA than in those who lost HCV RNA (P =.013). In conclusion, SENV infection was frequently found in patients with chronic hepatitis C. SENV infection had no apparent influence on the severity of HCV-related liver disease or the HCV response to IFN-alpha. SENV was sensitive to IFN-alpha therapy and the majority of patients had a sustained virologic response.
SEN病毒（SENV）是一种最近发现的单链环状DNA病毒。据报道，两种SENV变异体（SENV-D和SENV-H）与输血相关的非甲至戊型肝炎之间存在密切关联。为了阐明SENV感染对合并存在的慢性丙型肝炎的影响以及干扰素α（IFN-α）治疗对SENV复制的影响，采用聚合酶链反应对186例慢性丙型肝炎患者血清样本中的SENV DNA进行定量分析。186例慢性丙型肝炎患者中有39例（21%）SENV DNA呈阳性。SENV感染患者与未感染患者在临床、病毒学和组织学特征方面无差异。102例接受IFN-α治疗的慢性丙型肝炎患者中有18例SENV DNA呈阳性。SENV感染患者（28%）和未感染患者（39%）在IFN-α治疗后丙型肝炎病毒（HCV）清除的持续应答率无显著差异。16例患者中有15例在治疗期间SENV DNA水平下降，16例患者中有11例（69%）对IFN-α治疗出现SENV DNA持续消失。在合并感染患者中，未清除HCV RNA的患者对IFN-α的SENV应答明显优于清除HCV RNA的患者（P = 0.013）。总之，慢性丙型肝炎患者中经常发现SENV感染。SENV感染对HCV相关肝病的严重程度或HCV对IFN-α的应答无明显影响。SENV对IFN-α治疗敏感，大多数患者有持续病毒学应答。
