Omar Maisa, El-Din Samah Saad, Fam Nevine, Diab Manal, Shemis Mohamed, Raafat Manar, Seyam Moataz, Hssan Moataz, Badawy Afkar, Akl Maha, Saber Mohamed
Microbiology Department, Theodor Bilharz Research Institute, Cairo University, Giza, Egypt.
Medscape J Med. 2008;10(12):290. Epub 2008 Dec 24.
The SEN virus has been tentatively linked to transfusion-associated non-A to E hepatitis. The aim of the present study was to 1) determine the prevalence of SEN virus among Egyptian patients with hepatitis C virus (HCV)-related chronic liver disease and patients undergoing hemodialysis and 2) demonstrate the clinical effect of SEN virus infection on coexistent hepatitis C in terms of severity and probability of developing hepatocellular carcinoma. Polymerase chain reaction was used to detect SEN virus-D and SEN virus-H DNA in serum samples of 74 patients with HCV-related chronic liver disease, 45 uremic patients undergoing maintenance hemodialysis, and 28 healthy controls. SEN virus-D/H DNA was detected in 13.5% of patients with chronic liver disease, 11.1% of patients undergoing hemodialysis, and 7.1% of healthy controls, with no significant differences between patients and the control group. Clinical and biochemical measures did not significantly differ between SEN virus-infected and noninfected patients in the chronic liver disease group or the hemodialysis group. The rate of SEN virus infection was significantly higher in patients with chronic liver disease and hepatocellular carcinoma (33.3%) than in those with chronic liver disease only (8.5%) (P < .05). In conclusion, SEN virus does not seem to be a common infection in Egyptian patients. It has no apparent influence on the severity of coexistent HCV-related chronic liver disease but could be a risk factor for hepatocellular carcinoma in such patients. Further studies are needed to define the etiopathogenic role of SEN virus infection in the development of hepatocellular carcinoma.
SEN病毒初步被认为与输血相关的非甲至戊型肝炎有关。本研究的目的是：1）确定埃及丙型肝炎病毒（HCV）相关慢性肝病患者和接受血液透析患者中SEN病毒的流行率；2）从严重程度和发生肝细胞癌的可能性方面，证明SEN病毒感染对并存丙型肝炎的临床影响。采用聚合酶链反应检测74例HCV相关慢性肝病患者、45例接受维持性血液透析的尿毒症患者和28例健康对照者血清样本中的SEN病毒-D和SEN病毒-H DNA。慢性肝病患者中13.5%检测到SEN病毒-D/H DNA，血液透析患者中11.1%检测到，健康对照者中7.1%检测到，患者与对照组之间无显著差异。慢性肝病组或血液透析组中，SEN病毒感染患者与未感染患者的临床和生化指标无显著差异。慢性肝病合并肝细胞癌患者的SEN病毒感染率（33.3%）显著高于仅患有慢性肝病的患者（8.5%）（P<0.05）。总之，SEN病毒在埃及患者中似乎不是常见感染。它对并存的HCV相关慢性肝病的严重程度没有明显影响，但可能是此类患者发生肝细胞癌的危险因素。需要进一步研究来确定SEN病毒感染在肝细胞癌发生中的致病作用。
