Hall C A, London A R, Moynihan A C, Dodds W J
Br J Haematol. 1975 Feb;29(2):319-28. doi: 10.1111/j.1365-2141.1975.tb01826.x.
A large kindred with combined deficiencies of factors VII and IX is presented. The deficiencies appeared to be independent and the data were not consistent with a diagnosis of haemophilia BM. The identification of mildly affected family members, including carriers of haemophilia B and heterozygotes for factor-VII deficiency, was facilitated by comparison with the 95% confidence interval of an age- and sex-matched control population. The bleeding patterns were those of mild to moderate haemophilia B and did not appear to have been modified by the presence of factor-VII deficiency.
本文报道了一个患有因子 VII 和因子 IX 联合缺乏症的大家族。这些缺乏症似乎是独立存在的，且数据与血友病 B M 型的诊断不符。通过与年龄和性别匹配的对照人群的 95% 置信区间进行比较，有助于识别轻度受影响的家庭成员，包括血友病 B 的携带者和因子 VII 缺乏症的杂合子。出血模式为轻度至中度血友病 B，且似乎未因因子 VII 缺乏症的存在而改变。
