Molina H
Veteran's Administration Medical Center, St Louis, Missouri 63106, USA.
Cell Mol Life Sci. 2002 Feb;59(2):220-9. doi: 10.1007/s00018-002-8418-6.
Complement has an important role in inflammation and in the normal function of the immune system. Activated complement fragments have the capacity to bind and damage self-tissues. Cells from vertebrates express on their surface regulators of complement activation that protect them from the deleterious effects of cell-bound complement fragments. Abnormalities in these regulators of complement activation may participate in the pathogenesis of autoimmune diseases and inflammatory disorders. Murine Crry is one of these regulators that inhibits the activation of the third component of complement and protects self-tissues from complement-mediated damage. Experimental work on Crry has increased our understanding of the immunobiology of complement regulation and the potential role of complement and complement inhibitors in the development and treatment of human diseases.
补体在炎症反应和免疫系统的正常功能中发挥着重要作用。活化的补体片段具有结合并损伤自身组织的能力。脊椎动物的细胞在其表面表达补体激活调节因子，以保护自身免受结合在细胞上的补体片段的有害影响。这些补体激活调节因子的异常可能参与自身免疫性疾病和炎症性疾病的发病机制。小鼠Crry是这些调节因子之一，它能抑制补体第三成分的激活，并保护自身组织免受补体介导的损伤。对Crry的实验研究增进了我们对补体调节免疫生物学以及补体和补体抑制剂在人类疾病发生发展和治疗中潜在作用的理解。
