位于2号染色体q32区域的人类psiHSP40加工假基因的特征分析

Characterization of a processed pseudogene of human psiHSP40 on chromosome 2q32.

作者信息

Hata M, Kagotani K, Okumura K, Seto M, Ohtsuka K

机构信息

Cell and Stress Biology, Research Group, Aichi Cancer Research Center Research Institute, Nagoya, Japan.

出版信息

DNA Seq. 2001 Nov;12(4):293-7. doi: 10.3109/10425170109025006.

DOI:10.3109/10425170109025006

PMID:11916264

Abstract

A pseudogene for the human Hsp40 gene has been characterized (psiHSP40). The pseudogene sequence shows 90% similarity to the human Hsp40 mRNA at the nucleotide level. No introns were found in the region corresponding to the human Hsp40 cDNA, and two direct repeats flank this same region. Because of these features, the pseudogene can be classified as a processed pseudogene. PsiHSP40 was assigned to chromosome 2q32 by in situ hybridization. This is the first report of a pseudogene for a member of the DnaJ (Hsp40) family protein gene.

摘要

已对人类Hsp40基因的一个假基因（psiHSP40）进行了表征。该假基因序列在核苷酸水平上与人类Hsp40 mRNA具有90%的相似性。在对应于人类Hsp40 cDNA的区域未发现内含子，并且该相同区域两侧有两个直接重复序列。由于这些特征，该假基因可被归类为加工假基因。通过原位杂交将PsiHSP40定位于2号染色体q32区域。这是关于DnaJ（Hsp40）家族蛋白基因成员假基因的首次报道。