蓖麻毒素对MOPC - 315细胞中骨髓瘤蛋白（IgA）和一般细胞蛋白生物合成的影响。
Effect of ricin on biosynthesis of myeloma protein (IgA) and general cellular proteins in MOPC-315 cells.
作者信息
Ko T S, Kaji A
出版信息
Biochim Biophys Acta. 1975 Dec 4;414(2):155-60. doi: 10.1016/0005-2787(75)90218-x.
PMID:1191708
Abstract
Ricin, a phyto-toxin from the seeds of Ricinus communis, preferentially inhibits synthesis of myeloma protein by MOPC-315 cells as compared to the synthesis of general proteins. In contrast, cycloheximide inhibited equally both myeloma protein synthesis as well as general protein synthesis. These results suggest that proteins synthesized near or on cell membranes are more sensitive to Ricin which binds to the acceptor molecule on the plasma membrane.
摘要
蓖麻毒素是一种来自蓖麻种子的植物毒素，与一般蛋白质的合成相比，它优先抑制MOPC - 315细胞中骨髓瘤蛋白的合成。相比之下，环己酰亚胺对骨髓瘤蛋白合成和一般蛋白合成的抑制作用相同。这些结果表明，在细胞膜附近或细胞膜上合成的蛋白质对结合在质膜上受体分子的蓖麻毒素更为敏感。
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