Zimmerman J K
Biophys Chem. 1975 Oct;3(4):339-44. doi: 10.1016/0301-4622(75)80027-5.
The gel chromatographic patterns of a monomer-dimer-tetramer system under kinetic control have been studied by computer simulation. In no case do the derivative curves of the concentration profiles exhibit more than bimodality in these systems and in some cases are found to exist as a single, almost symmetric, peak. The monomer-dimer reaction affects the dimer-tetramer reaction only slightly and the same is true for the effect of the dimer-tetramer reaction on that of the monomer-dimer. All systems can be fit, to a first approximation, by an empirical formula which suggests any reaction with a first order half life within one and one half or two orders of the transport time will be under kinetic control.
通过计算机模拟研究了动力学控制下单体 - 二聚体 - 四聚体体系的凝胶色谱图。在这些体系中，浓度分布的导数曲线在任何情况下都不会表现出超过双峰性，并且在某些情况下被发现呈现为单个几乎对称的峰。单体 - 二聚体反应对二聚体 - 四聚体反应的影响很小，二聚体 - 四聚体反应对单体 - 二聚体反应的影响也是如此。所有体系在一阶近似下都可以用一个经验公式拟合，该公式表明任何半衰期在传输时间的一个半或两个数量级内的一级反应都将处于动力学控制之下。
