Qidwai Julie C, Watson Ginger S, Weiler John M
National Advanced Driving Simulator and Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, Iowa City 52244, USA.
Curr Allergy Asthma Rep. 2002 May;2(3):216-22. doi: 10.1007/s11882-002-0022-1.
First-generation antihistamines are well-known to cause subjective drowsiness. A myriad of studies has also been published that suggest a clear relationship between the use of these drugs and objective performance impairment. Although not all of the tests used in these studies have been validated, the data are fairly consistent, and suggest a difference between earlier (first-generation) sedating antihistamines and the newer (second-generation) nonsedating antihistamines.