Bárány E H
Ophthalmology. 1979 Jan;86(1):80-94. doi: 10.1016/s0161-6420(79)35548-8.
The histochemical distribution of carbonic anhydrase activity in the ciliary processes is shown. There is a multiplicity of possible points of attack of carbonic anhydrase inhibitors, We do not know which sites are critically inhibited at clinical dosage. One primary mechanism of the therapeutic action of miotics is ciliary muscle contraction, but on prolonged treatment, subsensitivity of the muscle may shift emphasis to miotic inhibition of aqueous secretion by unknown mechanisms. The trabecular meshwork is a slow tissue living off the aqueous. Aqueous composition in chronic simple glaucoma should therefore be studied with a view to possible treatment of the sick meshwork.
显示了睫状体中碳酸酐酶活性的组织化学分布。碳酸酐酶抑制剂有多种可能的作用靶点，我们不知道在临床剂量下哪些位点受到关键抑制。缩瞳剂治疗作用的一个主要机制是睫状肌收缩，但长期治疗后，肌肉的敏感性降低可能会将重点转移到通过未知机制抑制房水分泌的缩瞳作用上。小梁网是一种依赖房水生存的缓慢组织。因此，对于慢性单纯性青光眼患者，应该研究房水成分，以期对病变的小梁网进行可能的治疗。
