Bárány E H
Br J Pharmacol. 1985 Jan;84(1):193-8.
Intense muscarinic stimulation of the monkey ciliary muscle causes long-lasting muscarinic subsensitivity. This could be due to changes in number or affinity of muscarinic receptors which would cause a threshold elevation detectable in vivo. Since plasma levels of the agonists causing contraction in vivo were not available, the accommodation response to systemic muscarinic agents in subsensitized eyes was compared with that in the normal fellow eyes, usually seven days after a single subsensitizing dose of 100 micrograms carbachol to cornea. Subsensitivity was present whether the agonist tested was pilocarpine, carbachol or bethanechol but no evidence for threshold elevation was found. The conclusion is that changes in the muscarinic receptors are of minor importance for the kind of subsensitivity studied.
对猴睫状肌进行强烈的毒蕈碱刺激会导致持久的毒蕈碱敏感性降低。这可能是由于毒蕈碱受体数量或亲和力的变化，这会导致在体内可检测到阈值升高。由于无法获得体内引起收缩的激动剂的血浆水平，因此在通常给予角膜100微克卡巴胆碱单次致敏剂量七天后，将致敏眼对全身毒蕈碱药物的调节反应与正常对侧眼进行比较。无论测试的激动剂是毛果芸香碱、卡巴胆碱还是氯贝胆碱，均存在敏感性降低，但未发现阈值升高的证据。结论是，毒蕈碱受体的变化对于所研究的那种敏感性降低而言不太重要。
