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使用n个独立基因座估计交配系统的模型扩展。

Extensions of models for the estimation of mating systems using n independent loci.

作者信息

Ritland Kermit

机构信息

Department of Forest Sciences, University of British Columbia, Vancouver, BC V6T1Z4, Canada.

出版信息

Heredity (Edinb). 2002 Apr;88(4):221-8. doi: 10.1038/sj.hdy.6800029.

Abstract

Inferences about plant mating systems increasingly use highly informative genetic markers, and investigate finer facets of the mating system. Here, four extensions of models for the estimation mating systems are described. (1) Multiallelic probabilities for the mixed selfing-random mating model are given; these are especially suitable for microsatellites; a generalized Kronecker operator is basis of this formula. (2) Multilocus probabilities for the "correlated-matings model" are given; interestingly, comparisons between single- vs multilocus estimates of correlated-paternity can provide a new measure of population substructure. (3) A measure of biparental inbreeding, the "correlation of selfing among loci", is shown to approximate the fraction of selfing due to uniparental (as opposed to biparental) inbreeding; also joint estimation of 1- 2- and 3-locus selfing rates allow separation, under a simple model, of the frequency vs the magnitude of biparental inbreeding. (4) Method-of-moments estimators for individual outcrossing rates are given. Formulae are given for both gymnosperms and angiosperms, and the computer program "MLTR" implements these methods.

摘要

关于植物交配系统的推断越来越多地使用信息丰富的遗传标记,并研究交配系统的更细微方面。本文描述了用于估计交配系统的模型的四个扩展。(1)给出了混合自交-随机交配模型的多等位基因概率;这些特别适用于微卫星;广义克罗内克算子是该公式的基础。(2)给出了“相关交配模型”的多位点概率;有趣的是,相关父系单位点与多位点估计之间的比较可以提供一种新的种群亚结构度量。(3)一种双亲近亲繁殖的度量,即“位点间自交相关性”,被证明可以近似由于单亲(而非双亲)近亲繁殖导致的自交比例;在一个简单模型下,对一位点、二位点和三位点自交率的联合估计还可以区分双亲近亲繁殖的频率和程度。(4)给出了个体异交率的矩估计法。给出了裸子植物和被子植物的公式,计算机程序“MLTR”实现了这些方法。

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