Ajose A, Fasubaa B, Anetor J I, Adelekan D A, Makinde N O
Department of Chemical Pathology, College of Health Sciences, Obafemi Awolowo University, Ile-Ile, Nigeria.
Niger Postgrad Med J. 2001 Dec;8(4):161-4.
The impact of normal pregnancy on serum zinc and copper concentrations and on copper/zinc ratio has been determined in a cross-sectional study of eighty-four healthy pregnant Nigerian women. Fifty-seven healthy non-pregnant women served as controls. Serum zinc and copper levels were determined by atomic absorption spectroscopy. Mean serum copper concentration is significantly higher (P < 0.001) in the pregnant group than in controls [19.74(4.65) and 11.87(2.61) micromol/L respectively], while mean zinc level is significantly lower (P< 0.001) than in controls [4.40(1.34) and 5.54(1.04) micromol/L respectively. Copper/Zinc ratio is also significantly higher than (P<0.001) in the test subject [4.87(1.77) and 2.23(0.75) micromol/L respectively]. One-way analysis of variance shows that the mean serum zinc and copper concentrations and copper/zinc ratio differ significantly (P < 0.01, P < 0.05, and P < 0.05 respectively) between any two of the trimester groups. Furthermore, there is a significant positive correlation between gestational age and copper/zinc ratio (r- 0.201; P < 0.05), and a significant negative correlation between gestational age and serum zinc concentration (r = -0.274; P < 0.01). In normal pregnancy, a negative and positive linear relationship exists between gestational age and serum zinc level and copper/zinc ratio respectively. Serum copper does not show any significant trend throughout gestation, though pregnant subjects have higher mean serum copper level than controls.
在一项针对84名健康的尼日利亚孕妇的横断面研究中，已确定正常妊娠对血清锌和铜浓度以及铜/锌比值的影响。57名健康的非孕妇作为对照。血清锌和铜水平通过原子吸收光谱法测定。孕妇组的平均血清铜浓度显著高于对照组（P < 0.001）[分别为19.74(4.65)和11.87(2.61)微摩尔/升]，而平均锌水平显著低于对照组（P<0.001）[分别为4.40(1.34)和5.54(1.04)微摩尔/升]。铜/锌比值也显著高于测试对象（P<0.001）[分别为4.87(1.77)和2.23(0.75)微摩尔/升]。单因素方差分析表明，三个孕期组中任意两组之间的平均血清锌和铜浓度以及铜/锌比值存在显著差异（分别为P < 0.01、P < 0.05和P < 0.05）。此外，孕周与铜/锌比值之间存在显著正相关（r = 0.201；P < 0.05），孕周与血清锌浓度之间存在显著负相关（r = -0.274；P < 0.01）。在正常妊娠中，孕周与血清锌水平和铜/锌比值之间分别存在负向和正向线性关系。尽管孕妇的平均血清铜水平高于对照组，但血清铜在整个孕期未显示出任何显著趋势。
