Sato T, Nosaka E, Shibuya H, Momotani E, Fujii Y, Inoue J, Tezuka K, Shirai W
Laboratory of Veterinary Pathology, College of Bioresouce Sciences, Nihon University, Kameino, Fujisawa, Japan.
Avian Dis. 2002 Jan-Mar;46(1):256-9. doi: 10.1637/0005-2086(2002)046[0256:MLOTGI]2.0.CO;2.
A leiomyosarcoma was found in the gizzard of a 57-day-old female broiler chicken weighing 1.8 kg. Grossly, the tumor mass, 13.0 x 8.5 x 10.0 cm, enveloped the gizzard and had a gelatinous appearance due to the rich production of mucin. Miliary metastatic tumors were noted in the liver. Histopathologically, there was marked production of mucus throughout the tumor tissue, and densely or loosely arranged long spindle-shaped leiomyosarcoma cells proliferated. The tumor cells had a low rate of mitosis, showed slight cellular atypia, and, immunohistochemically, were positive for actin, alpha-smooth muscle actin, and desmin. Electron microscopically, various amounts of microfibrils with focal densities, dense patches, and basal plates were observed.
在一只57日龄、体重1.8千克的雌性肉鸡的肌胃中发现了平滑肌肉瘤。大体上，肿瘤块大小为13.0×8.5×10.0厘米，包裹着肌胃，由于大量产生粘蛋白而呈胶冻样外观。在肝脏中发现了粟粒状转移瘤。组织病理学上，整个肿瘤组织有大量粘液产生，密集或疏松排列的长梭形平滑肌肉瘤细胞增殖。肿瘤细胞有丝分裂率低，显示轻度细胞异型性，免疫组化显示肌动蛋白、α-平滑肌肌动蛋白和结蛋白呈阳性。电子显微镜下，观察到不同数量的微原纤维，伴有局灶性致密物、致密斑和基板。
