Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Vet Med Sci. 2024 Jul;10(4):e1520. doi: 10.1002/vms3.1520.
An 11-year-old female cinnamon cockatiel (Nymphicus hollandicus) was presented with a coelomic distention. Dystocia was suspected, given its previous history of a calcium-deficient diet and multiple instances of nonobstructive dystocia. Exploratory coeliotomy revealed a large intraluminal mass extending through the magnum to the uterus (shell gland). Metastasis and multiorgan involvement were not seen. Histopathologically, malignant and invasive fascicles of spindle cells were associated with abundant myxoid matrix and hypocellular areas. Multinucleation, bizarre cells and atypical mitotic figures were prominent. Masson's trichrome staining verified the muscular origin, and the myxoid matrix was demonstrated utilizing Alcian blue. The neoplastic cells exhibited alpha-smooth muscle actin and desmin immunoreactivity and were negative for vimentin. Thus, the patient was diagnosed with oviductal and uterine myxoid leiomyosarcoma (LMS). The patient survived 34 days post-surgery before death associated with suspected enteritis. Myxoid LMS is an extremely rare neoplasm in animals. To our knowledge, myxoid LMS has not been reported previously in pet birds.
一只 11 岁的雌性肉桂凤头鹦鹉（Nymphicus hollandicus）出现腹部肿胀。鉴于其先前存在钙缺乏饮食和多次非梗阻性难产的病史，怀疑为难产。剖腹探查发现一个大的腔内肿块从子宫角延伸到子宫（壳腺）。未发现转移和多器官受累。组织病理学上，恶性和侵袭性的梭形细胞束与丰富的黏液样基质和细胞稀少区相关。多核、奇异细胞和非典型有丝分裂象很明显。Masson 三色染色证实了肌肉起源，而黏液样基质则利用阿尔辛蓝进行了显示。肿瘤细胞表现出α-平滑肌肌动蛋白和结蛋白免疫反应性，而波形蛋白为阴性。因此，该患者被诊断为输卵管和子宫黏液样平滑肌肉瘤（LMS）。该患者在手术后 34 天死亡，死因疑似肠炎。黏液样 LMS 在动物中是一种极其罕见的肿瘤。据我们所知，宠物鸟类中尚未有报道过黏液样 LMS。
