Redies C, Luckner R, Arndt K
Institute of Anatomy, University of Essen, Essen, Germany.
Brain Res Bull. 2002;57(3-4):341-3. doi: 10.1016/s0361-9230(01)00724-9.
The cerebellar cortex of the chicken embryo contains parasagittal segments of Purkinje cells. At intermediate stages of development, cell-dense ribbons of migrating granule cells ("raphes") are found between the segments. The complementary pattern of granule cell raphes and Purkinje cell segments represents a basic scheme of cerebellar organization that coincides with the expression domains of various genes, such as cadherins, gene regulatory proteins, and ephrins and their receptors. We have recently found the raphe/segment pattern also in a mammalian species, the postnatal mouse. Like in the chicken, the parasagittal raphes of granule cells were observed at the boundaries of Purkinje cell segments that differentially express cadherins. The number and arrangement of the raphes in the different cerebellar lobules is roughly similar in both species. The raphe/segment pattern is thus more widely distributed in vertebrates than previously assumed.
鸡胚的小脑皮质包含浦肯野细胞的矢状旁节段。在发育的中间阶段，在这些节段之间可发现迁移的颗粒细胞（“中缝”）形成的细胞密集带。颗粒细胞中缝和浦肯野细胞节段的互补模式代表了小脑组织的基本架构，这与各种基因的表达域相吻合，如钙黏蛋白、基因调节蛋白、 Ephrin 及其受体。我们最近在一种哺乳动物——出生后的小鼠中也发现了中缝/节段模式。与鸡一样，在差异表达钙黏蛋白的浦肯野细胞节段边界处观察到颗粒细胞的矢状旁中缝。两种物种不同小脑小叶中缝的数量和排列大致相似。因此，中缝/节段模式在脊椎动物中的分布比之前认为的更广泛。
