Arndt K, Nakagawa S, Takeichi M, Redies C
Institute of Biology III, University of Freiburg, Germany.
Mol Cell Neurosci. 1998 Apr;10(5-6):211-28. doi: 10.1006/mcne.1998.0665.
In the developing chicken cerebellar cortex, three cadherins (Cad6B, Cad7, and R-cadherin) are expressed in distinct parasagittal segments that are separated from each other by ribbons of migrating interneurons and granule cells which express R-cadherin and Cad7, respectively. The segment/ribbon pattern is respected by the expression of other types of molecules, such as engrailed-2 and SC1/BEN/DM-GRASP. The cadherin-defined segments contain young Purkinje cells which are connected to underlying nuclear zones expressing the same cadherin, thereby forming parasagittal cortico-nuclear zones of topographically organized connections. In addition, R-cadherin-positive mossy fiber terminals display a periodic pattern in the internal granular layer. In this layer, Cad7 and R-cadherin are associated with synaptic complexes. These results suggest that cadherins play a pivotal role in the formation of functional cerebellar architecture by providing a three-dimensional scaffold of adhesive information.
在发育中的鸡小脑皮质中，三种钙黏蛋白（Cad6B、Cad7和R-钙黏蛋白）在不同的矢状旁区表达，这些区域被分别表达R-钙黏蛋白和Cad7的迁移中间神经元带和颗粒细胞带彼此分隔开。其他类型分子（如engrailed-2和SC1/BEN/DM-GRASP）的表达遵循这种区带/条带模式。由钙黏蛋白界定的区域包含年轻的浦肯野细胞，这些细胞与表达相同钙黏蛋白的下层核区相连，从而形成拓扑组织连接的矢状旁皮质-核区。此外，R-钙黏蛋白阳性的苔藓纤维终末在内部颗粒层呈现周期性模式。在该层中，Cad7和R-钙黏蛋白与突触复合体相关。这些结果表明，钙黏蛋白通过提供黏附信息的三维支架，在功能性小脑结构的形成中起关键作用。
