Reblet Concepción, Alejo A, Blanco-Santiago R I, Mendizabal-Zubiaga J, Fuentes M, Bueno-López J L
Department of Neurosciences, School of Medicine and Dentistry, The University of the Basque Country, Leioa, Spain.
Brain Res Bull. 2002;57(3-4):495-7. doi: 10.1016/s0361-9230(01)00719-5.
The lateral and ventral pallia have been proposed as the source of neurons for the insular and endopiriform claustra, respectively. However, this correlation is controversial. Here, we analysed this relationship by labelling radial glia in coronal slices of the telencephalon of paraformaldehyde-fixed rabbit embryos (E18-E28) and newborn rabbits with an anti-vimentin antibody or with the fluorescent dye DiI. The radial glia that crossed the claustrum was anchored to the neuroepithelium of the lateral ventricular angle (LVA) at all ages studied. The LVA was deep at E18, but it subsequently become shallower, because of the apposition of the portion of its walls proximal to the vertex of the LVA. At E18, the radial glia that crossed most of the insular claustrum extended from the lateral wall of the LVA (presumptive lateral pallium), and the radial glia that crossed either the most ventral part of the insular claustrum or the endopiriform claustrum proceeded from the medial wall of the LVA (presumptive ventral pallium). These results suggest that although the endopiriform claustrum originates from the ventral pallium, the insular claustrum originates from both the lateral and the ventral pallial portions.
外侧和腹侧大脑皮层分别被认为是岛叶和内梨状屏状核神经元的来源。然而，这种相关性存在争议。在这里，我们通过用抗波形蛋白抗体或荧光染料DiI标记多聚甲醛固定的兔胚胎（E18-E28）和新生兔端脑冠状切片中的放射状胶质细胞来分析这种关系。在所有研究的年龄段，穿过屏状核的放射状胶质细胞都锚定在侧脑室角（LVA）的神经上皮上。E18时LVA较深，但随后由于其靠近LVA顶点的壁部分相互贴近而变浅。在E18时，穿过大部分岛叶屏状核的放射状胶质细胞从LVA的外侧壁（推测为外侧大脑皮层）延伸而来，而穿过岛叶屏状核最腹侧部分或内梨状屏状核的放射状胶质细胞则从LVA的内侧壁（推测为腹侧大脑皮层）发出。这些结果表明，虽然内梨状屏状核起源于腹侧大脑皮层，但岛叶屏状核起源于外侧和腹侧大脑皮层部分。
