Bouvet Jean Pierre, Decroix Nipa, Pamonsinlapatham Perayot
Unité d'Immunopathologie Humaine, INSERM UR430, Hôpital Broussais, 75014, Paris, France.
Trends Immunol. 2002 Apr;23(4):209-13. doi: 10.1016/s1471-4906(02)02186-5.
Mucosal vaccines aim to prevent the penetration of pathogens, including HIV, into the body. Their cost can be low compared with curative therapies and thus, they are well suited to the fight against pandemic diseases in developing countries. Efficacy has been demonstrated for the oral poliovirus vaccine, but only very few other vaccines administered by the mucosal route are available commercially at present. Tremendous research efforts have now improved significantly the classical approach of these vaccines, and alternative methods of immunization, based on new concepts of mucosal immunity, are being developed.
黏膜疫苗旨在预防包括HIV在内的病原体侵入人体。与治疗性疗法相比，其成本可能较低，因此非常适合在发展中国家对抗大流行疾病。口服脊髓灰质炎疫苗已证明具有疗效，但目前通过黏膜途径给药的其他疫苗在商业上仅有极少数可用。现在，大量的研究工作已显著改进了这些疫苗的传统方法，并且基于黏膜免疫新概念的替代免疫方法正在研发中。
