du Plessis Adre J, Volpe Joseph J
Children's Hospital, 300 Longwood Avenue, Neurology - Fegan 11, Boston, Massachusetts, USA.
Curr Opin Neurol. 2002 Apr;15(2):151-7. doi: 10.1097/00019052-200204000-00005.
Major advances in understanding the cellular mechanisms of brain injury have presented a host of potential targets for intervention. This is particularly true of hypoxic-ischemic injury, the most important form of perinatal brain injury. As the window for effective clinical intervention may be particularly narrow in the fetus and newborn because of the often-delayed and subtle presentation of the onset of the insult, recent focus has been on defining and countering the more delayed mechanisms of brain injury. Recent insights into the mechanisms of oligodendrocyte injury and the role of inflammatory substances in perinatal brain injury are also discussed.
在理解脑损伤的细胞机制方面取得的重大进展带来了许多潜在的干预靶点。对于围产期脑损伤最重要的形式——缺氧缺血性损伤而言尤其如此。由于损伤发作的表现往往延迟且不明显，胎儿和新生儿的有效临床干预窗口可能特别狭窄，因此最近的重点一直是确定和对抗脑损伤更延迟的机制。本文还讨论了对少突胶质细胞损伤机制以及炎症物质在围产期脑损伤中的作用的最新见解。
