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乙醇用于腰椎间盘突出症的化学髓核溶解术。

Chemonucleolysis of lumbar disc herniation with ethanol.

作者信息

Riquelme C, Musacchio M, Mont'Alverne F, Tournade A

机构信息

Service de Neuroradiologie, Centre Hospitalier Louis Pasteur, 39, avenue de la Liberté, 68000 Colmar.

出版信息

J Neuroradiol. 2001 Dec;28(4):219-29.

Abstract

PURPOSE

To demonstrate the efficiency of the treatment of the lumbar disk herniation (LDH) with absolute alcohol.

MATERIALS/METHODS: From June 1997 to September 2000, 118 patients with 126 LDH, 69 males and 49 females, aged 19 to 77 (mean age: 51.1 years) were treated with absolute alcohol nucleolysis. In 75 cases, the LDH were parasagittal, in 30 foraminal, in 17 medial and in 4 extraforaminal. In most cases, the sensitive symptoms and motor or reflex abnormalities corresponded to the lumbar disc herniation level. Nucleolysis was made in ambulatory condition and each patient underwent general anesthesia. All procedures were performed in surgical conditions and controlled under digital fluoroscopy. The disc puncture was laterally made at the junction of middle and posterior thirds of the disc, under strict lateral fluoroscopic control. A discogram was obtained before ethanol injection. Injection dose of absolute alcohol was 0.4 ml. The realization time was about 15 minutes.

RESULT

Total improvement of symptoms was obtained in 97.55% of cases. Two patients remained with low-back pain and the failure treatment rate was 0.84% (1 case).

CONCLUSION

Nucleolysis with ethanol is a very effective, safe and low cost treatment for any kind of LDH, that allows to treat several levels during the same procedure, and can be repeated several times. Nucleolysis with ethanol can be made in ambulatory condition and be proposed to patients who refuse surgical treatment and have allergic background.

摘要

目的

证明无水乙醇治疗腰椎间盘突出症(LDH)的有效性。

材料/方法:1997年6月至2000年9月,118例患有126处腰椎间盘突出症的患者(男性69例,女性49例,年龄19至77岁,平均年龄:51.1岁)接受了无水乙醇溶核治疗。其中75例为旁矢状位腰椎间盘突出,30例为椎间孔型,17例为中央型,4例为椎间孔外型。多数情况下,敏感症状及运动或反射异常与腰椎间盘突出水平相对应。溶核治疗在门诊条件下进行,每位患者均接受全身麻醉。所有操作均在手术条件下进行,并在数字荧光透视控制下完成。在严格的侧位透视控制下,于椎间盘中外1/3交界处进行侧方椎间盘穿刺。在注射乙醇前进行椎间盘造影。无水乙醇注射剂量为0.4 ml。操作时间约15分钟。

结果

97.55%的病例症状得到完全改善。2例患者仍有腰痛,治疗失败率为0.84%(1例)。

结论

乙醇溶核术是一种治疗任何类型腰椎间盘突出症非常有效、安全且低成本的治疗方法,能够在同一次操作中治疗多个节段,并且可重复多次进行。乙醇溶核术可在门诊条件下实施,适用于拒绝手术治疗且有过敏史的患者。

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