van der Donk S, Buma P, Aspenberg P, Schreurs B W
Orthopedic Research Laboratory, Department of Orthopedics, University Medical Center Nijmegen, The Netherlands.
Comp Med. 2001 Aug;51(4):336-40.
Bone ingrowth has been studied extensively in rats by use of bone chambers. However, it is not known whether results in small animals, with respect to bone ingrowth processes, are similar in large animals, in which more realistic models are often used. Since the metabolic rate in small animals is, in general, higher than that in larger species, we hypothesized that bone ingrowth in chambers develops more rapidly in small animals. Therefore, identical bone chambers were placed in the tibias of rats and goats. After 6 and 12 weeks, histologic and histomorphometric examinations were carried out to measure bone and tissue ingrowth distances. Bone ingrowth was higher in both species at 12, compared with 6 weeks (P < 0.01). Tissue ingrowth in general (including soft tissue) was less in rats than in goats at both time periods (P < 0.001). However, bone ingrowth did not differ between species. Thus, when differences in size of an osseous defect are corrected for, there seems to be only little influence of differences in body size.
通过使用骨腔室，已经在大鼠中对骨长入进行了广泛研究。然而，就骨长入过程而言，尚不清楚小动物的结果在通常使用更符合实际模型的大动物中是否相似。由于一般来说，小动物的代谢率高于较大物种，我们推测腔室内的骨长入在小动物中发展得更快。因此，将相同的骨腔室置于大鼠和山羊的胫骨中。在6周和12周后，进行组织学和组织形态计量学检查以测量骨和组织长入距离。与6周时相比，两种物种在12周时的骨长入均更高（P < 0.01）。在两个时间段，大鼠的组织长入（包括软组织）总体上均少于山羊（P < 0.001）。然而，物种之间的骨长入没有差异。因此，当校正骨缺损大小的差异时，体型差异似乎只有很小的影响。
