Doi Yumi, Minami Toshiaki, Nishizawa Mikio, Mabuchi Tamaki, Mori Hidemaro, Ito Seiji
Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan.
Neuroreport. 2002 Jan 21;13(1):93-6. doi: 10.1097/00001756-200201210-00022.
Prostacyclin (PGI2) is well known to play crucial roles in induction of edema and pain behavior in the periphery. In the present study, we investigated the central role of PGI2 in inflammatory pain. Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice. Intrathecal administration of the IP agonist cicaprost induced mechanical hyperalgesia 6 h after carrageenan injection. These results suggest that PGI2 is involved in pain transmission at the spinal cord following expression of IP receptor mRNA induced by peripheral inflammation.
前列环素（PGI2）在外周水肿和疼痛行为的诱导中发挥关键作用，这一点广为人知。在本研究中，我们探究了PGI2在炎性疼痛中的中枢作用。足底注射角叉菜胶可显著诱导前列环素受体（IP受体）mRNA的表达，在6小时时达到最大值，同时诱导环氧化酶（COX-2）的诱导型表达，尽管在未处理小鼠的脊髓中IP受体mRNA表达较弱。鞘内注射IP激动剂西卡前列素在角叉菜胶注射后6小时诱导机械性痛觉过敏。这些结果表明，PGI2参与了外周炎症诱导IP受体mRNA表达后脊髓水平的疼痛传递。
