Romero J C, Ott C E, Aguilo J J, Torres V E, Strong C G
Circ Res. 1975 Nov;37(5):683-9. doi: 10.1161/01.res.37.5.683.
Hypertensive rabbits with a clip on the renal artery of their solitary remaining kidney show an abrupt decrease in blood pressure after the arterial constriction is released. Although the mechanism underlying this phenomenon remains controversial, some experimental evidence suggests that it could be humorally mediated. The involvement of prostaglandins was investigated by examining the effect of the release of the arterial constriction on blood pressure, renal blood flow, glomerular filtration rate, and urinary output in five conscious single-kidney hypertensive rabbits in which prostaglandin synthesis was blocked with indomethacin (priming intravenous injection of 9 mg/kg followed by a constant infusion of 1 mg/kg hour-1). The results were compared with those obtained in another group of five single-kidney hypertensive rabbits submitted to the same protocol but not treated with indomethacin. The blockade of prostaglandin synthesis with indomethacin prevented the increments in renal blood flow and glomerular filtration rate seen in the control rabbits after unclipping a significantly retarded the appearance of diuresis and the fall in blood pressure. Despite these observations, the results do not indicate a major participation of prostaglandins in the reversal of single-kidney hypertension, because the decrease in blood pressure 9 hours after the removal of the arterial constriction was similar in both groups.
在仅存的一个肾脏的肾动脉上夹闭的高血压兔，在解除动脉狭窄后血压会突然下降。尽管这一现象背后的机制仍存在争议，但一些实验证据表明可能是体液介导的。通过检查在五只清醒的单肾高血压兔中解除动脉狭窄对血压、肾血流量、肾小球滤过率和尿量的影响，来研究前列腺素的作用。这五只兔用消炎痛阻断前列腺素合成（静脉注射首剂9mg/kg，随后以1mg/kg·小时-1持续输注）。将结果与另一组五只接受相同实验方案但未用消炎痛治疗的单肾高血压兔的结果进行比较。消炎痛阻断前列腺素合成可防止在解除夹闭后对照兔肾血流量和肾小球滤过率的增加，并显著延迟利尿的出现和血压的下降。尽管有这些观察结果，但结果并不表明前列腺素在单肾高血压的逆转中起主要作用，因为在解除动脉狭窄9小时后两组的血压下降情况相似。
