Omata K, Abe K, Chiba S, Yasujima M, Sato M, Kudo K, Hagino T, Yoshinaga K, Otsuka Y
Prostaglandins Leukot Med. 1986 Dec;25(2-3):163-73. doi: 10.1016/0262-1746(86)90063-6.
To determine the role of endogenous prostaglandins and sodium balance in the maintenance of high blood pressure in chronic two-kidney, one clip hypertension in rats, we studied the effect of indomethacin infusion on the reversal of hypertension by unclipping. Indomethacin was infused after control measurements, and blood pressure was monitored continuously in conscious rats. Parallel control experiments and sham operations were also performed. Inhibition of prostaglandin synthesis did not affect the postoperative course of blood pressure after the unclipping operation despite the marked decrease of urinary prostaglandin E excretion. The decrease of blood pressure after unclipping was significantly correlated with plasma renin activity prior to unclipping. Sodium balance was not significantly different between the experimental groups. These data indicate no major participation of prostaglandins in the reversal of chronic two-kidney, one clip hypertension, and suggest that the renin angiotensin system participates, at least in part, in the maintenance of high blood pressure in this model of hypertension.
为了确定内源性前列腺素和钠平衡在大鼠慢性两肾一夹高血压模型中维持高血压的作用，我们研究了吲哚美辛输注对去夹后高血压逆转的影响。在进行对照测量后输注吲哚美辛，并对清醒大鼠的血压进行连续监测。同时还进行了平行对照实验和假手术。尽管尿中前列腺素E排泄量显著降低，但抑制前列腺素合成并未影响去夹手术后的血压变化过程。去夹后血压下降与去夹前血浆肾素活性显著相关。各实验组之间的钠平衡无显著差异。这些数据表明前列腺素在慢性两肾一夹高血压的逆转中没有主要作用，并提示肾素 - 血管紧张素系统至少部分参与了该高血压模型中高血压的维持。
