Atabek H B, Ling S C, Patel D J
Circ Res. 1975 Dec;37(6):752-61. doi: 10.1161/01.res.37.6.752.
A nonlinear theory of pulsatile flow was used to investigate the detailed flow field in the left circumflex coronary artery of anesthetized open-chest dogs. Studies were carried out under a wide range of blood pressures and flow rates induced by intravenous infusions of dipyridamole. The results indicated that (1) the flow profiles, although less blunt than those in the descending aorta, are still nonparabolic, (2) the wall shear in the coronary arteries maintains a high value through diastole, and (3) during intravenous infusions of dipyridamole both coronary flow and wall shear increase. The peak value of the shear stress during these infusions, which reached 360 dynes/cm2, can approach the yield stress value of 400 dynes/cm2 reported by Fry for endothelial cells.
采用脉动流非线性理论研究了麻醉开胸犬左旋冠状动脉内的详细流场。在静脉输注双嘧达莫诱导的广泛血压和流速范围内进行了研究。结果表明：（1）血流剖面虽不如降主动脉中的那样钝，但仍呈非抛物线形；（2）冠状动脉壁切应力在整个舒张期保持较高值；（3）静脉输注双嘧达莫时，冠状动脉血流和壁切应力均增加。这些输注过程中切应力峰值达到360达因/平方厘米，可接近Fry报道的内皮细胞400达因/平方厘米的屈服应力值。
